How it is WORKS??

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The PATHOGENESIS.

Love patterns? Ovarian pathogenesis goes by patterns of spread ;

  1. Local spread: intraperitoneally
  2. Peritoneal carcinosis: intraperitoneal spread after rupture of the ovarian capsule
  3. Lymphatic metastasis: para-aortic lymph nodes, in rare cases retrograde invasion of inguinal or femonal lymph nodes
  4. Hematogenous metastasis: liver, lung CNS, in rare cases bone involvement
Molecular abnormalities identified in patients with epithelial ovarian cancer.
  • Mutation in the p53 protooncogene, B-raf, K-ras, PTEN or 8-catenin
  • Amplification of HER2
  • Over expression of HER2
  • Expression of angiogenic cytokines such as vascular endothelial growth factor(VEGF)

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